NAD+ is short for Nicotinamide adenine dinucleotide and it is a co-enzyme that is critical for life. It is found, naturally, in every living cell in your body where it plays an important part in numerous biological pathways.

NAD+ is essential in the Krebs Cycle, which turns food molecules into energy. It enables DNA repair and cellular regeneration. NAD+ also works with the neuro-transmission of signals between neurons (including in the brain).

Lower levels of NAD+ result in your cells not being able to metabolise as much of the food molecules as may be needed, making less energy available for you to use. As cells replicate, DNA is damaged and, without repairing this damage, copies of this damage can be passed on to future replications of the cells. Without the NAD+ supporting neurotransmission between cells, so the signal generated by one neuron is not passed on as efficiently as possible to the next, leading to a weaker, slower signal. These slow signals add up to cogitative slowing and even cogitative decline.

There are four possible routes which can be used to top up your NAD+ levels.

1. Orally: NAD+ can be swallowed in pill form, but the bioavailability (the amount your body can absorb) is extremely low as NAD+ is a fragile molecule and is broken down during digestion. NAD+ precursor molecules can also be consumed and are more stable through digestion but there are questions over the safety of such supplements. The FDA is currently investigating these precursors as there may be side effects, such as cancer, caused by heavy consumption of these supplements.
2. Intravenous injection: The fastest way to boost your NAD+ levels is through IV drip, where 500mg of NAD+ can be administered in a matter of hours. The downside of this is that the experience can be deeply unpleasant, with strong tightening of the chest, waves of extreme nausea and a “sensation of drowning” has also been reported. It also requires a nurse to administer and can take 4 hours. The huge boost to the system wears off over the course of about a month and another IV drip is then required to top up again.
3. Intramuscular injection: An effective way to maintain NAD+ levels in the body is to have small IM injections of NAD+ every other day. This tops-up the system very effectively, but has its own side effect of being an extremely painful injection into the muscle. It also requires “drawing up” (taking the NAD+ from a vial into the syringe) and involves long needles, which many customers are uncomfortable with. Finally, the IM injection requires the customer to find someone to inject them or for them to inject themselves, which is also tricky for many customers.
4. Sub-cutaneous injection (sub.cut.): The NAD+ PEN (patent pending) is the first sub.cut. Auto-injector pen for NAD+. It precisely administers the right amount of NAD+ 4mm under the skin… which is exactly where the fatty layer is. This fatty layer has fewer nerves than muscle and a slower blood flow, resulting in significantly less painful injection. The dose is small and administered every other day to build up and then maintain your healthy NAD+ levels.

Using the NAD+ PEN, you should build up your NAD+ levels over the first three days of use by taking a dose on day 1, 2 and 3. After the first three days, you should use your NAD+ PEN every other day. We recommend taking the NAD+ in the morning so you can enjoy the benefits of your top up throughout the day.

The NAD+ PEN is the easiest, most painless and most convenient way to top up your NAD+ levels

INSERT/REPLACE THE NAD+ CARTRIDGE
1. Remove the lid by pulling it away from the base
2. Unscrew the clear glass piece from the base
3. Push down the black plunger with your finger to reset it
4. Slide a new cartridge into the clear holder and, with the metal cap facing the top if the pen, reattaching it by screwing on firmly.

1. Remove the lid from the pen & check that the cartridge has enough NAD+ solution in it. If not,
2. Take a 4mm needle tip from the pack and gently but firmly screw it on to the end of the pen. Do not remove the needle tip cover yet.
3. Clean the injection site with an alcohol wipe provided in the pack. It is good to select a fatty area, such as the belly, buttock or thigh.
4. Remove the needle tip covers (there is an inner and an outer one – remove both)
5. Without putting the pen down, twist the base until the pointer lines up with your dose, usually 20 units, which is 0.2ml.
6. Hold the pen so the needle points up. Tap the pen few times to move the air bubble to the top and slide the plunger enough to push the air out before you give the shot.
7. Gently pinch the skin around the injection site to pull it away from the muscle a little (it only needs to be 4mm away so don’t pull hard!)
8. Place the pen on the injection site & press the pen down to penetrate skin.
9. Firmly press the button at the base of the pen. This will depress the plunger and administer the NAD+. A slight stinging sensation is normal.
10. Once the dial has returned to zero (0), count down three seconds to ensure the entire dose is administered and then remove the needle.
11. Remove the pen cover, replace the larger needle tip cover carefully & unscrew the needle tip + cover.
12. Put the pen lid back on & dispose of the needle tip in your regular household waste.

The NAD+ PEN should be stored, with its active cartridge of NAD+, between 2 and 8 degrees Celsius (35.6-46.4 Fahrenheit). A domestic fridge is a great place. If you are travelling, it is highly recommended to use an insulated case with ice packs.

NAD+ cartridges that are not yet being used should be stored in a freezer.

NAD+ can last for 18 months if kept chilled, at the correct temperature. We are incredibly careful to make sure that you are only buying the freshest NAD+ from us, and so have put expiry dates on the vials. Please reference these and do not use any NAD+ that has passed these dates.

The NAD+ must remain chilled in transit, so we use some specially designed packaging, with integrated cooling, to be certain that you get your NAD+ in the best possible condition. The packaging and cooling will maintain the right temperature for 48 hours (2 days) so when there are expected delays with postage (such as over bank weekends), we may delay shipping to ensure your NAD+ doesn’t sit for too long and warm up.

YES. Your cartridges can contain 3ml when filled to the top, but doing so makes it much more likely for the bung to come out in transit. As a result, we sent you two cartridges with just over 1.5ml in each. We slightly over-fill each cartridge so you get every dose you need throughout the month, despite losing a few drops along the way (clearing any bubbles, discarded with the needle, human error etc).